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KMID : 0616120120430020157
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Korean Journal of Pharmacognosy
2012 Volume.43 No. 2 p.157 ~ p.162
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Immunostimulating Effect of Mycelium Extract of Phellinus linteus
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Lee Byung-Eui
Ryu Shi-Yong
Kim Eui-Han
Kim Young-Hee
Kwak Kyung-A
Song Ho-Yeon
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Abstract
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In order to investigate the immunostimulating effect of mycelia extract of Phellinus linteus (PLM) on human monocyte THP-1 and rat peritoneal macrophage cell, we examined measuring cytokine secretion (IL-6 and TNF-). The production of IL-6 and TNF-a in human monocyte THP-1 was slight increased dose-dependently when the cells were challenged with PLM for 72 hrs. It was also observed that the treatment of PLM with LPS augmented the production of IL-6 and TNF-a in human monocyte THP-1. It was also observed that the treatment of PLM with LPS augmented the production of IL-6 and TNF- in human monocyte THP-1. The production of IL-6 and TNF- in rat peritoneal macrophage was significantly enhanced when the cells were treated PLM with LPS for 72 hrs. Moreover, the proliferation rate of rat spleen cells was increased in a dose dependent manner as the cells were treated with PLM and Concanavalin A.
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KEYWORD
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Phellinus linteus mycelium, Immunostimulation, Cytokine, Peritoneal macrophage cell, Rat spleen cell
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